The first research spotlight will be on Wednesday, December 4th at 3:00-3:30 PM ET. This meeting will feature Dr. Tim Kamp from the University of Wisconsin.
Abstract: The adult human heart following a large myocardial infarction is unable to regenerate heart muscle and instead forms scar with the risk of progressive heart failure. Large animal studies have shown that intramyocardial injection of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) following a myocardial infarction result in cell grafts but also ventricular arrhythmias. In this research spotlight, results will be presented from a preclinical study to evaluate the biomanufacturing, safety, and efficacy of intramyocardial injection of committed cardiac progenitor cells derived from iPSCs, combined with cardiac fibroblast-derived extracellular matrix to enhance cell retention that suggests a promising new avenue for treating heart failure.
Message from RMIP Leadership
The leadership teams would like to express their sincere gratitude to the studies led by Dr. Corey Neu for meeting to discuss the data linkage strategy.
A special thanks to the study teams who have already uploaded the requested study documentation to the NIH box including:
IRB approved study protocol
Letter of IRB approval
Informed consent template
Applicable HIPAA consent form
The study documentation provides essential information needed to properly interpret results and prepare the data for sharing. If you haven’t, please do so as soon as possible. Let's continue this momentum and make these projects a success!
Many thanks from the RMIP Leadership
Aron Marquitz
Candace Kerr
Rahul Thakar
Sweta Ladwa
Recent Publications
Congratulations to the following study teams for their recent publications or preprints:
S.S Lee, …, and L.A. Garza. The use of ectopic volar fibroblasts to modify skin identity. Science. 2024 Sep 6;385(6713):eadi1650. DOI: 10.1126/science.adi1650
A.N. Raval, …, and T.J. Kamp. Human iPSC-derived Committed Cardiac Progenitors Generate Cardiac Tissue Grafts in a Swine Ischemic Cardiomyopathy Model without Triggering Ventricular Arrhythmias. bioRxiv 2024 Feb 14; 580375; doi: https://doi.org/10.1101/2024.02.14.580375.
Meet with us
BDC now has office hours each Wednesday from 2:00 to 3:00 PM ET to assist investigators with aggregating and harmonizing RMIP study data on the ecosystem.
We continue to coordinate one-on-one meetings with study teams to discuss a data linkage strategy. This strategy will ensure that the cell characterization data is prepared and formatted appropriately for seamless sharing with the study team. The goal is to facilitate efficient data transfer and analysis.
Mike Enger
November 2024 RMIP Updates
RMIP Research Spotlight
The first research spotlight will be on Wednesday, December 4th at 3:00-3:30 PM ET. This meeting will feature Dr. Tim Kamp from the University of Wisconsin.
Abstract: The adult human heart following a large myocardial infarction is unable to regenerate heart muscle and instead forms scar with the risk of progressive heart failure. Large animal studies have shown that intramyocardial injection of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) following a myocardial infarction result in cell grafts but also ventricular arrhythmias. In this research spotlight, results will be presented from a preclinical study to evaluate the biomanufacturing, safety, and efficacy of intramyocardial injection of committed cardiac progenitor cells derived from iPSCs, combined with cardiac fibroblast-derived extracellular matrix to enhance cell retention that suggests a promising new avenue for treating heart failure.
Message from RMIP Leadership
The leadership teams would like to express their sincere gratitude to the studies led by Dr. Corey Neu for meeting to discuss the data linkage strategy.
A special thanks to the study teams who have already uploaded the requested study documentation to the NIH box including:
IRB approved study protocol
Letter of IRB approval
Informed consent template
Applicable HIPAA consent form
The study documentation provides essential information needed to properly interpret results and prepare the data for sharing. If you haven’t, please do so as soon as possible. Let's continue this momentum and make these projects a success!
Many thanks from the RMIP Leadership
Aron Marquitz
Candace Kerr
Rahul Thakar
Sweta Ladwa
Recent Publications
Congratulations to the following study teams for their recent publications or preprints:
Meet with us
BDC now has office hours each Wednesday from 2:00 to 3:00 PM ET to assist investigators with aggregating and harmonizing RMIP study data on the ecosystem.
We continue to coordinate one-on-one meetings with study teams to discuss a data linkage strategy. This strategy will ensure that the cell characterization data is prepared and formatted appropriately for seamless sharing with the study team. The goal is to facilitate efficient data transfer and analysis.
Resources, Materials and Support
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RMIP BDC Office Hours Wednesday 2:00-3:00PM ET
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