RMIP Research Spotlight - Dr. Graca Almeida-Porada
M
Mike Enger
started a topic
about 1 month ago
Join us for the upcoming RMIP Research Spotlight featuring Dr. Graça Almeida-Porada of Wake Forest University and the Wake Forest Institute for Regenerative Medicine.
RMIP Research Spotlight on Thursday, March 20th at 12:00-1:00 PM ET: Register today!
Current hemophilia A (HA) treatments, relying on frequent FVIII infusions, face challenges including high cost, limited global access, and inhibitor development. Prenatal therapy (PNTx) offers a potential cure by circumventing immune barriers and inducing FVIII tolerance. Large animal studies have demonstrated sustained FVIII expression using human placental cells (PLCs) transduced with a lentiviral vector encoding a bioengineered FVIII transgene (mcoET3). In this research spotlight we present results from a preclinical study to manufacture, characterize, and authenticate a gene-modified PLC-based hemophilia A therapeutic product, and confirm therapeutic potential and safety in mouse and large animal PNTx models.
We hope that you will be able to join us for this spotlight.
Mike Enger
Join us for the upcoming RMIP Research Spotlight featuring Dr. Graça Almeida-Porada of Wake Forest University and the Wake Forest Institute for Regenerative Medicine.
RMIP Research Spotlight on Thursday, March 20th at 12:00-1:00 PM ET: Register today!
Current hemophilia A (HA) treatments, relying on frequent FVIII infusions, face challenges including high cost, limited global access, and inhibitor development. Prenatal therapy (PNTx) offers a potential cure by circumventing immune barriers and inducing FVIII tolerance. Large animal studies have demonstrated sustained FVIII expression using human placental cells (PLCs) transduced with a lentiviral vector encoding a bioengineered FVIII transgene (mcoET3). In this research spotlight we present results from a preclinical study to manufacture, characterize, and authenticate a gene-modified PLC-based hemophilia A therapeutic product, and confirm therapeutic potential and safety in mouse and large animal PNTx models.
We hope that you will be able to join us for this spotlight.