Join us for the next RMIP Research Spotlight featuringDr. Luis Garza of Johns Hopkins University School of Medicine.
RMIP Research Spotlight on Thursday, June 25th at 1:00-2:00 PM ET. Register Today!
Dr. Luis Garza is a professor and Vice-Chair of Research in the Department of Dermatology at the Johns Hopkins University School of Medicine where he leads a molecular dermatology laboratory and practices at Johns Hopkins outpatient clinics. His research centers on skin stem cells, wound healing, and regenerative medicine, with a focus on how innate immunity, noncoding endogenous RNA, and mediators can be harnessed to shift healing from scarring toward true regeneration and to treat conditions like alopecia and chronic wounds. His work has redefined fundamental understanding of skin biology and is driving next-generation therapeutic strategies.
Presentation Abstract: Amputees who use prosthetics may find them painful or result in skin problems at the stump site. In part, this arises because the skin at the stump site is not naturally designed to bear weight, making it difficult for the site to adapt to pressure or tolerate mechanical loads. Preclinical work demonstrated that volar fibroblast transplantation increases markers of volar skin such as keratin 9 expression, epidermal thickness, and extracellular matrix remodeling, leading to skin that is more pressure resistant and less prone to breakdown. This clinical research employs a regenerative strategy in which ectopic volar fibroblasts are extracted from the palm and sole of the foot the palm and autologously transplanted into the stump site. Dr. Luis Garza of Johns Hopkins University School of Medicine will present on an ongoing phase 2 clinical trial in lower-limb amputees is testing the efficacy of this approach to reduce ulceration, pain, and prosthesis-related complications, thereby improving function and quality of life for amputees.
Jeran Stratford
Join us for the next RMIP Research Spotlight featuring Dr. Luis Garza of Johns Hopkins University School of Medicine.
RMIP Research Spotlight on Thursday, June 25th at 1:00-2:00 PM ET. Register Today!
Dr. Luis Garza is a professor and Vice-Chair of Research in the Department of Dermatology at the Johns Hopkins University School of Medicine where he leads a molecular dermatology laboratory and practices at Johns Hopkins outpatient clinics. His research centers on skin stem cells, wound healing, and regenerative medicine, with a focus on how innate immunity, noncoding endogenous RNA, and mediators can be harnessed to shift healing from scarring toward true regeneration and to treat conditions like alopecia and chronic wounds. His work has redefined fundamental understanding of skin biology and is driving next-generation therapeutic strategies.
Presentation Abstract: Amputees who use prosthetics may find them painful or result in skin problems at the stump site. In part, this arises because the skin at the stump site is not naturally designed to bear weight, making it difficult for the site to adapt to pressure or tolerate mechanical loads. Preclinical work demonstrated that volar fibroblast transplantation increases markers of volar skin such as keratin 9 expression, epidermal thickness, and extracellular matrix remodeling, leading to skin that is more pressure resistant and less prone to breakdown. This clinical research employs a regenerative strategy in which ectopic volar fibroblasts are extracted from the palm and sole of the foot the palm and autologously transplanted into the stump site. Dr. Luis Garza of Johns Hopkins University School of Medicine will present on an ongoing phase 2 clinical trial in lower-limb amputees is testing the efficacy of this approach to reduce ulceration, pain, and prosthesis-related complications, thereby improving function and quality of life for amputees.